Zylkene® Equine

Est-ce efficace? OUI!

Les études sur la molécule Zylkene® ont été menées sur des rats, des chiens, des chats, des chevaux et des humains.¹²³⁴⁵⁶ Lors de deux études cliniques publiées,⁷⁸ il a été prouvé que Zylkene® Equine facilitait la transition du cheval vers un nouvel environnement et réduisait le stress lors de procédures multiples telles que l’entraînement, les soins vétérinaires et les soins de ferrage.

Zylkene® est-il sécuritaire? YES!

• Aucun effet secondaire connu.
• Aucune désinhibition (perte d’inhibition).
• Aucune perte d’efficacité au fil du temps.
• Aucun développement de dépendance au fil du temps.

1. Miclo, Laurent, et al. “Characterization of α-casozepine, a tryptic peptide from bovine αs1-casein with benzodiazepine-like activity.” The FASEB Journal 15.10 (2001): 1780-1782.

2. Guesdon, Benjamin, et al. “A tryptic hydrolysate from bovine milk α s1-casein improves sleep in rats subjected to chronic mild stress.” Peptides 27.6 (2006): 1476-1482

3. Violle, Nicolas, et al. “Ethological comparison of the effects of a bovine α S1-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety.” Pharmacology Biochemistry and Behavior 84.3 (2006): 517-523.

4. Messaoudi, Michaël, et al. “Anxiolytic-like effects and safety profile of a tryptic hydrolysate from bovine alpha s1-casein in rats.” Fundamental & clinical pharmacology 23.3 (2009): 323-330.

5. Beata, Claude, et al. “Effects of alpha-casozepine (Zylkene®) versus selegiline hydrochloride (Selgian, Anipryl) on anxiety disorders in dogs.” Journal of Veterinary Behavior: Clinical Applications and Research 2.5 (2007): 175-183.

6. Beata, Claude, et al. “Effect of alpha-casozepine (Zylkene®) on anxiety in cats.” Journal of Veterinary Behavior: Clinical Applications and Research 2.2 (2007): 40-46.

7. McDonnell, Sue M., Jaime Miller, and Wendy Vaala. “Calming benefit of short-term alpha-casozepine supplementation during acclimation to domestic environment and basic ground training of adult semi-feral ponies.” Journal of Equine Veterinary Science 33.2 (2013): 101-106.

8. McDonnell, Sue M., Jaime Miller, and Wendy Vaala. “Modestly Improved Compliance and Apparent Comfort of Horses With Aversions to Mildly Aversive Routine Health Care Procedures Following Short- Term Alpha-Casozepine Supplementation.” Journal of Equine Veterinary Science 34.8 (2014): 1016-1020.